副教授Associate Professor
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杨立昆
发布人:王青  发布时间:2017-01-01   动态浏览次数:251

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副教授 硕士生导师


邮箱:yanglikun@ouc.edu.cn

电话:0532-85906579




承担课程:

代谢生物化学、细胞生物学实验

 

学习工作经历:

2009~2013,中国海洋大学海洋生命学院,学士,生物科学

2013~2015,中国海洋大学海洋生命学院,硕士研究生(公派出国), 海洋生物学

2015~2019,美国奥本大学,博士,生物医学(生理学)

2019~2021,美国埃默里大学,博士后

2021至今,中国海洋大学海洋生命学院,讲师、副教授

 

 

主要科研领域:

主要从事海洋无脊椎动物发育过程调控机制及环境适应分子基础研究,以尾索动物海鞘为模式,聚焦于幼虫环境信号感知及附着变态调控机制解析。近年来研究成果在国际主流刊物发表SCI论文10余篇。主持承担了国家自然科学基金青年项目、国家重点研发计划项目(子任务)、山东省自然科学基金青年项目、中国博士后基金面上项目等。 

 

代表性成果:(#共同第一;*通讯作者)

 

1. Yang, L. K.#, Wang, W.#, Guo, D. Y., Dong, B.*. (2025). Non-canonical signaling initiated by hormone-responsive G protein-coupled receptors from subcellular compartments. Pharmacology & Therapeutics. 266:108788.

2. Yang, L. K., Zhang, J., Liu, D., Han, T. Y., Qin, Q. S., Wang, A. Q., Dong, B.*. (2023). Ancestral glycoprotein hormone and its cognate receptor present in primitive chordate ascidian: Molecular identification and functional characterization. International Journal of Biological Macromolecules. 229: 401-412.

3. Wang, Z., Ouyang, X., Tan, Z., Yang, L. K. *, Dong, B. (2023). Quantitative phosphoproteomics reveals the requirement of DYRK1-mediated phosphorylation of ion transport- and cell junction-related proteins for notochord lumenogenesis in ascidian. Cells. 12: 921.

4. Zhang, J., Dong, B. *, & Yang, L. K.* (2022). Molecular Characterization and Expression Analysis of Putative Class C (Glutamate Family) G Protein-Coupled Receptors in Ascidian Styela clava. Biology, 11(5): 782.

5. Yang, L. K.#, Hou, Z. S.#, & Tao, Y. X.* (2021). Biased signaling in naturally occurring mutations of G protein-coupled receptors associated with diverse human diseases. Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease, 1867(1):165973.

6. Yang, L. K. & Tao, Y. X.* (2020). Alanine scanning mutagenesis of the DRYxxI motif and intracellular loop 2 of human melanocortin-4 receptor. International Journal of Molecular Sciences, 21(20):7611.

7. Yang, L. K., Zhang, Z. R., Wen, H. S., & Tao, Y. X.* (2019). Characterization of channel catfish (Ictalurus punctatus) melanocortin-3 receptor reveals a potential network in regulation of energy homeostasis. General and Comparative Endocrinology, 277:90-103.

8. Yang, L. K. & Tao, Y. X.* (2019). Physiology and pathophysiology of the b3-adrenerigic receptor. Progress in Molecular Biology and Translational Science, 161:91-112.

9. Yi, T. L.#, Yang, L. K.#, Ruan, G. L., Yang, D. Q., & Tao, Y. X.* (2018). Melanocortin-4 receptor in swamp eel (Monopterus albus): Cloning, tissue distribution, and pharmacology. Gene, 678:79-89.

10. Yang, L. K. & Tao, Y. X.* (2017). Biased signaling at neural melanocortin receptors in regulation of energy homeostasis. Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease, 1863:2486-2495.

11. Pan, C., Kang, J., Hwang, J.S., Li, J., Boese, A.C., Wang, X., Yang, L., Boggon, T.J., Chen, G.Z., Saba, N.F., Shin, D.M., Magliocca, K.R., Jin, L., Kang, S.* (2021). Cisplatin-mediated activation of glucocorticoid receptor induces platinum resistance via MAST1. Nature communications, 12(1):1-15.


电话:0532-82032720 | Email:zgwang@ouc.edu.cn | 联系地址:青岛市鱼山路5号

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