特邀学术报告——刘柏岐博⼠

报告题目： The gene regulatory network in the anterior neural plate border of ascidian embryos

报告⼈：刘柏岐 博⼠    日本京都⼤学 理学院动物系

刘柏岐，现为日本京都⼤学理学院动物系博⼠后研究员。本科就读于西北农林⼤学，哈⼯⼤硕⼠，京都⼤学博⼠。其目前⼯作的主要⽅向为动物器官发育调控信号的进化机制。最近的研究发现调控脊椎动物下颌形成的信号通路在脊索动物中是保守的，暗示了下颌基板起源进化的细胞类群和前体器官。成果发表在《Nature Communications》 。

The cranial placodes are thickenings of embryonic ectoderm and give rise to multiple cranial sensory organs and ganglia in vertebrate head. It has been proposed that the emergency of cranial placodes is one of key characteristics to distinguish vertebrates and other chordates. However, recent studies have shown that the anterior neural plate border (ANB) in ascidians, closest relatives of vertebrates, has similarities with vertebrate placodes. The study of gene regulatory network (GRN) in ANB cells is required for further understanding the evolutionary origin of cranial placodes. In present study, we found that Foxg, a conserved transcription factor, began to be expressed in ANB cells at the early neurula stage under the control of Foxc and MAPK signaling pathway. Ephrina.d negatively regulated the MAPK signaling pathway to restrict Foxg expression domain. Knockdown of Foxg affected the formation of the derivatives of ANB cells. Because Foxg is important for specification of cranial placodes in vertebrate embryos, our results provide additional evidence suggesting that the ascidian ANB cells and vertebrate cranial placodes share an evolutionary origin.

时 间： 2020.8. 31（周⼀） 9:30-11:00

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