English
中文
董波
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教育经历
1993-1997，中国海洋大学，海水养殖专业，学士
1997-2000，中国科学院海洋研究所，水产养殖，硕士
2001-2005，中国科学院海洋研究所，海洋生物学，博士
2006-2010，挪威卑尔根大学萨斯国际海洋分子生物学中心，发育生物学，博士后
工作经历
2010-2014，日本理化学研究所神户发育生物学中心，国际特别研究员
2014-至今，中国海洋大学，海洋生命学院，“筑峰人才工程”特聘教授
2020-至今，中国海洋大学，方宗熙海洋生物进化与发育研究中心，PI
主要研究方向及成果
主要从事海洋动物遗传学与环境适应演化机制研究，以进化节点动物海鞘和模式动物果蝇为实验材料，通过遗传学、细胞发育生物学和生物物理学等多学科交叉途径开展研究。在入侵物种器官形态发生的遗传学基础、宿主环境适应性演化分子机制以及宿主与共生微生物协同演化机制等领域取得了重要进展，发现了新型生物管腔形成方式和调控细胞及器官形态发生的重要信号通路，解析了海鞘逆行变态的细胞学过程、机械力驱动机制及诱导变态的分子和神经信号传递调控通路，建立了生物管腔几何形态维持及腔液膨胀的数学物理模型，阐明了海鞘合子基因组激活调控机制以及海鞘入侵的基因组学遗传基础。研究成果以通讯作者身份发表在Science Advances，Nature Communications，PNAS、PLoS Biology、Current Biology，NAR、eLife、Cell Reports、SCLS、Development、MER等领域主流刊物发表论文140 余篇，他引3000次。多篇文章被选为期刊亮点、期刊点评及Faculty of 1000专家推荐。
现任国际被囊动物学会学术指导委员会委员，《Marine Life Science & Technology》基础生物学领域主编，《Developmental Biology》执行编委，主持承担了国家科技部重点研发计划生物安全关键技术专项、政府间国际科技合作重点专项、山东省重大研发专项以及国家自然科学基金等多个项目。2014年至今任中国海洋大学“筑峰计划”特聘教授、青岛市创新创业领军人才、山东省有突出贡献中青年专家、山东省“泰山学者”特聘教授、国家万人计划科技创新领军人才。
作为项目负责人主持项目包括
▪ 国家重点研发计划“生物安全关键技术研究”重点专项项目：外来水生生物对水域生态系统的影响及入侵风险评估和防控（2022YFC2601300，2022.11-2025.10；1800万）
▪ 崂山实验室科技创新项目（山东省重大科技创新工程专项）（LSKJ202203200，2022.10-2026.09；1200万）
▪ 国家重点研发计划“政府间国际科技创新合作”重点专项项目：细胞外基质在管腔器官形态发生与稳态维持中的角色和功能研究（2019YFE0190900，2020.01-2022.12；270万）
▪ 崂山实验室科技创新项目（山东省重大科技创新工程专项）课题：特征器官的发育调控与谱系溯源（LSKJ202203002， 2022.05-2025.04；200万）
▪ 国家基金面上项目：真海鞘肠道微生物组学解析及活性成分功能鉴定(2020-2023)
▪ 国家基金面上项目：软骨调节素在海鞘脊索腔液形成中的分子调控机制(2018-2021)
▪ 国家基金面上项目：小窝蛋白在海洋模式动物海鞘脊索发育中的角色(2016-2019)
▪ 山东省重大科技创新工程专项课题：海洋动物个体发育与系统演化遗传基础(2018-2021)
1. Jiang A. #, Han K#, Wei J. #, Su X. #,Wang R., Zhang W., Liu X., Qiao J., Liu P., Liu Q., Zhang J. , Zhang N., Ge Y., Zhuang Y., Yu H., Wang S., Chen K., Xu X., Yang H, Fan G*, Dong B.*. Spatially-resolved single-cell atlas of ascidian endostyle provides insights into the origin of vertebrate pharyngeal organs. Science Advances, 2024, 10 (13), eadi9035.
2. Wei J. #, Zhang W. #, Jiang A#, Peng H. #, Zhang Q. #, Li Y., Bi J., Wang L., Liu P., Wang J., Ge Y., Zhang L., Yu H., Li L., Wang S., Leng L.*, Chen K.*, Dong B.* Spatiotemporal hierarchy and allele-specific expression of zygotic genome activation revealed by distant interspecific urochordate hybrids. Nature Communications, 2024, 15, 2395.
3. Peng H., Qiao J., Wang G., Shi W., Xia F., Qiao R., Dong B.* A collagen-rich arch in the urochordate notochord coordinates cell shaping and multi-tissue elongation. Current Biology, 2023, 33: 1-14.
4. Lin B., Shi W., Lu Q., Shito T., Yu H., Dong B.* Establishment of a developmental atlas and transgenetic tools in the ascidian Styela clava. Marine Life Sciences & Technology. 2023. https://doi.org/10.1007/s42995-023-00200-2
5.Wei J.#, Liu, P.#, Liu F.#, Jiang A., Qiao J, Pu Z., Wang B., Zhang J., Jia D., Li Y.*, Wang S.* and Dong B*. EDomics: a comprehensive and comparative multiomics database for animal evo-devo. Nucleic Acids Research. 2023, 51, D913–D923.
6. Liu A., Ouyang X., Wang Z., Dong B.* ELMOD3-Rab1A-Flotillin2 cascade regulates lumen formation via vesicle trafficking in Ciona notochord. Open Biology. 2023, 13: 220367
7. Ouyang X. Wu B., Yu H., Dong B*. DYRK1-mediated phosphorylation of endocytic components is required for extracellular lumen expansion in ascidian notochord. Biological Research. 2023, 56: 10.
8. Wang Z., Tan Z., Bi J., Liu A., Jiang A., Dong B*. Proteomic identification of intracellular vesicle trafficking and protein glycosylation requirements for lumen inflation in Ciona notochord. Proteomics. 2023. e2200460. (Cover)
9. Fu Y.#, Lv Z.#, Kong D., Fan Y., Dong B*, High abundance of CDC45 inhibits cell proliferation through elevation of HSPA6. Cell proliferation. 2022, e13257. doi:10.1111/cpr.13257.
10. Zhao L#, Gao F#, Gao S#, Liang Y#, Long H#, Lv Z#, Su Y#, Ye N#, Zhang L#, Zhao C#, Wang X, Song W*, Zhang S*, Dong B*, Biodiversity-based development and evolution: The emerging research systems in model and non-model organisms. Science China Life Sciences. 2021, 64(8):1236-1280. https://doi.org/10.1007/s11427-020-1915-y.
11. Lu Q#, Gao Y#, Fu Y, Peng H, Shi W, Li B, Lv Z, Feng X, Dong B*, Ciona embryonic tail bending is driven by asymmetrical notochord contractility and coordinated by epithelial proliferation. Development. 2020. 147. doi:10.1242/dev.185868. (Research highlight. This article has an associated ‘The people behind the papers’ interview)
12. Wei J, Zhang J, Lu Q, Ren P, Guo X, Wang J, Li X, Chang Y, Duan S, Wang S, Yu H, Zhang X, Yang X, Gao H, Dong B*, Genomic basis of environmental adaptation in the leathery sea squirt (Styela clava). Molecular Ecology Resources. 2020; 20:1414-1431.https://doi.org/10.1111/1755-0998.13209 (Spotlight paper)
13. Bhattachan P, Rae J, Yu H, Jung W, Wei J, Parton R G*, and Dong B*, Ascidian caveolin induces membrane curvature and protects tissue integrity and morphology during embryogenesis. The FASEB Journal, 2020, 34 (1): 1345-1361.
14. Lu Q, Bhattachan P, Dong B*. Ascidian notochord elongation, Developmental Biology. 2019, 448：147-153.
15. Zhang X, Liu X, Liu C, Wei J, Yu H, Dong B*. Identification and characterization of microRNAs involved in ascidian larval metamorphosis. BMC Genomics. 2018, 19(1):168
16. Wei J, Wang G, Li X, Ren P, Yu H, Dong B*. Architectural delineation and molecular identification of extracellular matrix in ascidian embryos and larvae. Biology Open. 2017, 6(9): 1383-1390. (Cover)
17. 董波*。海洋模式动物海鞘及其脊索发育与调控。科学通报，2015，60: 1167-1179.
18. Sehring I, Recho P, Denker E, Kourakis M, Mathiesen B, Hannezo E*, Dong B*, Jiang D*. Assembly and positioning of actomyosin rings by contractility and planar cell polarity. eLife. 2015, 4: e09206. (Highlight; Recommendation by Faculty of 1000)
19. Hannezo E#,*, Dong B#,*, Recho P, Joanny JF, Hayashi S. A cortical instability drives periodic supracellular actin pattern formation in epithelial tubes. PNAS. 2015, 112 (28): 8620-8625. (Commentary by Gov, McSharry, and Beitel)
20. Dong B, Hayashi S*. Shaping of biological tubes by mechanical interaction of cell and extracellular matrix. Current Opinion in Genetics & Development, 2015, 32: 129-134.
21. Sehring I#, Dong B#, Denker E, Bhattachan P, Deng W, Mathiesen B, Jiang D*. An equatorial contractile mechanism drives cell elongation but not cell division. PLoS Biology, 2014,12(2): e1001781. (Synopsis by M. Hoff; Recommendation by Faculty of 1000)
22. Dong B*, Hannezo E, Hayashi S*. Balance between apical membrane growth and luminal matrix resistance determines the shape of epithelial tubule. Cell Reports. 2014, 7(4): 941-950.
23. Dong B, Miao GX, Hayashi S*. A fat body-derived apical extracellular matrix enzyme is transported to the tracheal lumen and is required for tube morphogenesis in Drosophila. Development, 2014 141 (21): 4104-4109. (Highlight of current issue)
24. Dong B, Kakihara K, Otani T, Wada H, Hayashi S*. Rab9 and retromer regulate retrograde trafficking of luminal protein required for epithelial tube length control. Nature Communications. 2013, 4, 1358.
25. Dong B, Deng W, Jiang D*, Distinct cytoskeleton populations and extensive crosstalk control Ciona notochord tubulogenesis. Development, 2011, 138 (8): 1631-1641. (Recommendation by Faculty of 1000)
26. Dong B, Horie T, Denker E, Kusakabe T, Tsuda M, Smith WC, Jiang D*. Tube formation by complex cellular processes in Ciona intestinalis notochord. Developmental Biology, 2009, 330: 237-249.
