Lisui Bao

Professor

Education

2005-2009, Ocean University of China, Biotechnology & Computer Science and Technology, Double BA Degrees

2011-2017, Auburn University (US), Aquatic Genomics, Ph.D 

Research experiences

2017-2020, University of Chicago (US), Postdoctoral Scholar

2021-2023, Ocean University of China, Associate Professor

2023-present, Ocean University of China, Professor

Main research directions and interests

Being engaged in functional genomics research for a long time, responsible for and participated in the research and development of a series of large-scale omics projects. Having rich working experience, especially in the direction of genome assembly strategy with highly repetitive sequences, sex determination mechanism, multi-omics analysis of aquatic adaptive traits and genome structural variations, etc, and having mastered advanced omics technology and theoretical accumulation. Papers have been published as a first or a corresponding author in journals such as Nat Ecol Evol, Nat Cancer, Nat Commun, BMC Biol, Mol Ecol Resour, Cell Discov, etc.

Representative publications (#equal contribution; *corresponding author)

1. Han W#, Liu L#, Wang J#, Wei H#, Li Y#, Zhang L#, Guo Z, Li Y, Liu T, Zeng Q, Xing Q, Shu Y, Wang T, Yang Y, Zhang M, Li R, Yu J, Pu Z, Lv J, Lian S, Hu J, Hu X, Bao Z, Bao L*, Zhang L*, Wang S*. (2022) Ancient homomorphy of molluscan sex chromosomes sustained by reversible sex-biased genes and sex determiner translocation. Nature Ecology & Evolution. 6: 1891-1906. (Cover Story; Behind the Paper: The 'forever-young' secret of scallop sex chromosomes: exceptions to the 'general' rules)

2. Bao, L., Zhong, X., Yang, Y., Yang L.* (2022). Starfish infers signatures of complex genomic rearrangements across human cancers. Nat Cancer https://doi.org/10.1038/s43018-022-00404-y

3. Bao, L., Tian, C., Liu, S., Zhang, Y., Elaswad, A., Yuan, Z., Khalil, K., Sun, F., Yang, Y., Zhou, T., Li, N., Tan, S., Zeng, Q., Liu, Y., Li, Y., Li, Y., Gao, D., Dunham, R., Davis, K., Waldbieser, G. and Liu, Z.* (2019). The Y chromosome sequence of the channel catfish suggests novel sex determination mechanisms in teleost fish. BMC Biol 17(1): 6.

4. Liu, Z.#*, Liu, S.#, Yao, J.#, Bao, L.#, Zhang, J.#, Li, Y.#, Jiang, C., Sun, L., Wang, R., Zhang, Y., Zhou, T., Zeng, Q., Fu, Q., Gao, S., Li, N., Koren, S., Jiang, Y., Zimin, A., Xu, P., Phillippy, A. M., Geng, X., Song, L., Sun, F., Li, C., Wang, X., Chen, A., Jin, Y., Yuan, Z., Yang, Y., Tan, S., Peatman, E., Lu, J., Qin, Z., Dunham, R., Li, Z., Sonstegard, T., Feng, J., Danzmann, R., Schroeder, S., Scheffler, B., Duke, M., Ballard, L., Kucuktas, H., Kaltenboeck, L., Liu, H., Armbruster, J., Xie, Y., Kirby, M. L., Tian, Y., Flanagan, M., Mu, W. and Waldbieser, G. (2016). The channel catfish genome sequence provides insights into the evolution of scale formation in teleosts. Nat Commun 7.

5. He, Y.#, Chang, Y.#, Bao, L.#, Yu, M.#, Li, R.#, Niu, J., Fan, G., Song, W., Seim, I., Qin, Y., Li, X., Liu, J., Kong, X., Peng, M., Sun, M., Wang, M., Qu, J., Wang, X., Liu, X., Wu, X., Zhao, X., Wang, X., Zhang, Y., Guo, J., Liu, Y., Liu, K., Wang, Y., Zhang, H., Liu, L., Wang, M., Yu, H., Wang, X., Cheng, J., Wang, Z., Xu, X., Wang, J., Yang, H., Lee, S. M., Liu, X.*, Zhang, Q.* and Qi, J.* (2019). A chromosome-level genome of black rockfish, Sebastes schlegelii, provides insights into the evolution of live birth. Mol Ecol Resour 19(5): 1309-1321.

6. Li, Y.#, Wang, R.#, Xun, X.#, Wang, J.#, Bao, L.#, Thimmappa, R.#, Ding, J.#, Jiang, J.#, Zhang, L., Li, T., Lv, J., Mu, C., Hu, X., Zhang, L., Liu, J., Li, Y., Yao, L., Jiao, W., Wang, Y., Lian, S., Zhao, Z., Zhan, Y., Huang, X., Liao, H., Wang, J., Sun, H., Mi, X., Xia, Y., Xing, Q., Lu, W., Osbourn, A., Zhou, Z.*, Chang, Y.*, Bao, Z.* and Wang, S*. (2018). Sea cucumber genome provides insights into saponin biosynthesis and aestivation regulation. Cell Discov 4: 29.

7. Zeng, Q.#, Liu J.#, Wang C.#, Wang H., Zhang L., Hu J., Bao L.* and Wang S.* (2021). High-quality reannotation of the king scallop genome reveals no ‘gene-rich’ feature and evolution of toxin resistance. Comput. Struct. Biotechnol. J. 19: 4954-4960.

8. Wang, H.#, Lv J.#, Zeng Q.*, Liu Y., Xing Q., Wang S., Hu J. and Bao L.* (2021). Genetic differentiation and selection signatures in two bay scallop (Argopecten irradians) breeds revealed by whole-genome resequencing analysis. Aquaculture 543: 736944.

9. Dai X.#, Zhu X.#, Bao L.#, Chen X., Miao Y., Li Y., Li Y., Lv J., Zhang L., Huang X., Bao Z., Wang S.*, Wang J.*  (2022). Decoding the byssus fabrication by spatiotemporal secretome analysis of scallop foot. Comput Struct  Biotechnol J 20:2713-2722.