教育经历

1993-1997，中国海洋大学，海水养殖专业，学士

1997-2000，中国科学院海洋研究所，水产养殖，硕士

2001-2005，中国科学院海洋研究所，海洋生物学，博士

2006-2010，挪威卑尔根大学萨斯国际海洋分子生物学中心，发育生物学，博士后

工作经历

2020-至今，中国海洋大学，方宗熙海洋进化发育生物学研究中心，PI

2014-至今，中国海洋大学，海洋生命学院，“筑峰计划”特聘教授

2010-2014，日本理化学研究所神户发育生物学中心，国际特别研究员

主要研究方向及成果

主要从事动物遗传发育生物学研究，以进化节点动物海鞘和模式动物果蝇为实验材料，通过遗传学、细胞发育生物学和生物物理学等多学科交叉途径，研究囊泡极性运输、细胞骨架动态、胞外基质物理特性及其对细胞行为的影响等。在器官发育和稳态维持机制等方面取得重要进展，发现了脊索管腔形成的细胞学过程，揭示了调控细胞及器官形态发育变化的重要信号通路，建立了决定生物管腔几何形状的数学物理模型。研究成果发表在PNAS, PLoS Biology, eLife, Nature Communications，Cell Reports，Development、FASEB J等领域主流刊物。2014年至今，获得青岛市创新创业领军人才、山东省“泰山学者”特聘教授、山东省有突出贡献中青年专家等荣誉称号。现任中国海洋湖沼学会理事，《Marine Life Science & Technology》，《BMC   Genomics》和《中国海洋大学学报》(自然科学版)等期刊编委。主持科技部重点研发计划政府间重点专项、国家基金和山东省重大研发等多个项目。

代表性文章

1.Wei J.^#, Liu, P.^#, Liu F.^#, Jiang A., Qiao J, Pu Z., Wang B., Zhang J., Jia D., Li Y.*, Wang S,* and Dong B*. EDomics: a comprehensive and comparative multiomics database for animal evo-devo. Nucleic Acids Research 2023, 51, D913–D923.

2. Liu A., Ouyang X., Wang Z., Dong B.* ELMOD3-Rab1A-Flotillin2 cascade regulates lumen formation via vesicle trafficking in Ciona notochord. Open Biology 2023, 13: 220367

3. Ouyang X. Wu B., Yu H., Dong B*. DYRK1-mediated phosphorylation of endocytic components is required for extracellular lumen expansion in ascidian notochord. Biological Research2023, 56: 10.

4. Wang Z., Tan Z., Bi J., Liu A., Jiang A., Dong B*. Proteomic identification of intracellular vesicle trafficking and protein glycosylation requirements for lumen inflation in Ciona notochord. Proteomics 2023. e2200460.

5. Fu Y. ^#, Lv Z. ^#, Kong D., Fan Y., Dong B^*. High abundance of CDC45 inhibits cell proliferation through elevation of HSPA6. Cell proliferation, 2022, e13257. doi:10.1111/cpr.13257.

6.Sun X, Zhang X, Yang L, Dong B^*. A microRNA cluster-Lefty pathway is required for cellulose synthesis during ascidian larval metamorphosis. Frontiers in Cell and Developmental Biology, 2022, 10:835906. doi: 10.3389/fcell.2022.835906.

7. Zhao L^#, Gao F^#, Gao S^#, Liang Y^#, Long H^#, Lv Z^#, Su Y^#, Ye N^#, Zhang L^#, Zhao C^#, Wang X, Song W^*, Zhang S^*, Dong B^*. Biodiversity-based development and evolution: The emerging research systems in model and non-model organisms. Science China Life Sciences, 2021, 64(8):1236-1280. https://doi.org/10.1007/s11427-020-1915-y.

8. Peng H, Qiao R, Dong B^*, Polarity establishment and maintenance in ascidian notochord. Frontiers in Cell and Developmental Biology, 2020, 8: 597446. doi: 10.3389/fcell.2020.597446.

9. Lu Q^#, Gao Y^#, Fu Y, Peng H, Shi W, Li B, Lv Z, Feng X, Dong B^*. Ciona embryonic tail bending is driven by asymmetrical notochord contractility and coordinated by epithelialproliferation. Development, 2020,147. (Researchhighlight. This article has an associated ‘The people behind the papers’interview)

10. Wei J, Zhang J, Lu Q, Ren P, Guo X, Wang J, Li X, Chang Y, Duan S, Wang S, Yu H, Zhang X, Yang X, Gao H, Dong B^*, Genomic basis of environmental adaptation in the leathery sea squirt (Styela clava). Molecular Ecology Resources, 2020, 00:1–18. (Spotlight paper)

11.B hattachan P, Rae J, Yu H, Jung W, Wei J, Parton RG^*, and Dong B^*, Ascidian caveolin induces membrane curvature and protects tissue integrity and morphology during embryogenesis. The FASEB Journal, 2020, 34 (1): 1345-1361.

12. Lv Z, Lu Q, Dong B^*, Morphogenesis: a focus on marine invertebrates. Marine Life Science & Technology, 2019, 1: 28-40.

13. Lu Q, Bhattachan P, Dong B^*. Ascidian notochord elongation, Developmental Biology, 2019, 448: 147-153.

14. 董波*。海洋模式动物海鞘及其脊索发育与调控。科学通报, 2015, 60: 1167-1179.

15. Sehring I, Recho P, Denker E, Kourakis M, Mathiesen B, Hannezo E^*, Dong B^*, Jiang D^*. Assembly and positioning of actomyosin rings by contractility and planar cell polarity. eLife, 2015, 4: e09206. (Highlight; Recommendation by Faculty of 1000).

16. Hannezo E^#*, Dong B^#*, Recho P, Joanny JF, Hayashi S. A cortical instability drives periodic supracellular actin pattern formation in epithelial tubes. Proceedings of the National Academy of Sciences USA, 2015, 112(28): 8620-8625. (Commentary by Gov, McSharry, and Beitel).

17. Dong B, Hayashi S. Shaping of biological tubes by mechanical interaction of cell and extracellular matrix. Current Opinion in Genetics & Development, 2015, 32: 129-134.

18. Sehring I^#, Dong B^#, Denker E, Bhattachan P, Deng W, Mathiesen B, Jiang D. An equatorial contractile mechanism drives cell elongation but not cell division. PLoS Biology, 2014, 12(2): e1001781. (Synopsis by M. Hoff; Recommendation by Faculty of 1000).

19. Dong B^*, Hannezo E, Hayashi S^*. Balance between apical membrane growth and luminal matrix resistance determines the shape of epithelial tubule. Cell Reports, 2014, 7(4): 941-950.

20. Dong B, Miao GX, Hayashi S. A fat body-derived apical extracellular matrix enzyme is transported to the tracheal lumen and is required for tube morphogenesis in Drosophila. Development, 2014, 141 (21): 4104-4109. (Highlight of current issue).

21. Dong B, Kakihara K, Otani T, Wada H, Hayashi S. Rab9 and retromer regulate retrograde trafficking of luminal protein required for epithelial tube length control. Nature Communications, 2013, 4: 1358.

22. Dong B, Deng W, Jiang D, Distinct cytoskeleton populations and extensive crosstalk control Ciona notochord tubulogenesis. Development, 2011, 138 (8): 1631-1641. (Recommendation by Faculty of 1000).

23. Dong B, Horie T, Denker E, Kusakabe T, Tsuda M, Smith WC, Jiang D. Tube formation by complex cellular processes in Ciona intestinalis notochord. Developmental Biology, 2009, 330: 237-249.