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Shi WANG

Shi WANG

发布者：王秉柔 发布时间：2020-09-03 浏览次数：185

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  Shi WANG，PhD

Professor, Ocean University of China

Vice-Dean of the College of Marine Life Sciences

Email: swang@ouc.edu.cn

Tel: 0532-85906589

Lab Website：http://www.molevolab.org

Academic Qualifications

1998-2002, B.S., Biotechnology, Ocean University of China,

2002-2007, Ph.D, Genetics, Ocean University of China,

2007-2009, Postdoc, University of Texas at Austin, Integrative Biology

2009-2010, Postdoc, University of Texas at Austin, Neurobiology

Working Experience

2011-present, Professor, Ocean University of China, College of Marine Life Sciences

2020-present, PI, Ocean University of China, Fang Zongxi Center

Research Interests

Our group is particularly interested in marine molluscan genomics. During recent years, we have made high-impact achievements in the development of a series of cutting-edge genomic techniques for non-model organisms and made key findings in the developmental evolution of animal body plan diversity, trunk eye development and larval origin. The ultimate goal of our group is to utilize interdisciplinary techniques and methods to systematically elucidate the macroevolution mechanisms of animal development, as well as the genomic and morphological evolution of molluscs.

Representative Publications（#equal contribution；*corresponding author）

Note, for most recent publications, please visit: https://www.researchgate.net/profile/Shi_Wang3/

      1. Yu H#, Li Y#,*, Han W, Bao L, Liu F, Ma Y, Pu Z, Zeng Q, Zhang L, Bao Z, Wang S*. (2023) Pan-evolutionary and regulatory genome architecture delineated by integrated macro-and microsynteny approach. Nature Protocols. Accepted. 

2. Wei J#, Liu P#, Liu F#, Jiang A, Qiao J, Pu Z, Wang B, Zhang J, Jia D, Li Y*, Wang S*, Dong B*. (2022) EDomics: a comprehensive and comparative multi-omics database for animal evo-devo. Nucleic Acids Research. 51(D1): D913-D923.

3. Han W#, Liu L#, Wang J#, Wei H#, Li Y#, Zhang L#, Guo Z, Li Y, Liu T, Zeng Q, Xing Q, Shu Y, Wang T, Yang Y, Zhang M, Li R, Yu J, Pu Z, Lv J, Lian S, Hu J, Hu X, Bao Z, Bao L*, Zhang L*, Wang S*. (2022) Ancient homomorphy of molluscan sex chromosomes sustained by reversible sex-biased genes and sex determiner translocation. Nature Ecology & Evolution. 6: 1891-1906. 

4. Thimmappa R*, Wang S#, Zheng M#, Misra RC, Huang AC, Saalbach G, Chang Y, Zhou Z, Hinman V, Bao Z, Osbourn A*. (2022) Biosynthesis of saponin defensive compounds in sea cucumbers. Nature Chemical Biology. 18: 774-781.

5. Sun Z#, Huang S#,*, Zhu P, Tzehau L, Zhao H, Lv J, Zhang R, Zhou L, Niu Q, Wang X, Zhang M, Jing G, Bao Z, Liu J, Wang S*, Xu J*. (2022) Species-resolved sequencing of low-biomass or degraded microbiomes using 2bRAD-M. Genome Biology. 23: 36.

6. Liu F, Li Y*, Yu H, Zhang L, Hu J, Bao Z, Wang S*. (2021) MolluscDB: an integrated functional and evolutionary genomics database for the hyper-diverse animal phylum Mollusca. Nucleic Acids Research. 49: D988-D997.

7. Bao Y#, Zeng Q#, Wang J#, Zhang Z#, Zhang Y#, Wang S#, Wong N#, Yuan W, Huang Y, Zhang W, Liu J, Lv L, Xue Q, Zha S, Peng Z, Yao H, Bao Z, Wang S*, Lin Z*. (2021) Genomic insights into the origin and evolution of molluscan red-bloodedness in the blood clam Tegillarca granosa. Molecular Biology and Evolution. 38: 2351-2365.

8. Wang J#, Zhang L#, Lian S#, Qin Z#, Zhu X#, Dai X, Huang Z, Ke C, Zhou Z, Wei J, Liu P, Hu N, Zeng Q, Dong B, Dong Y, Kong D, Zhang Z, Liu S, Xia Y, Li Y, Zhao L, Xing Q, Huang X, Hu X, Bao Z, Wang S*. (2020) Evolutionary transcriptomics of metazoan biphasic life cycle supports a single intercalation origin of metazoan larvae. Nature Ecology & Evolution. 4: 725-736.

9. Lv J#, Jiao W#, Guo H#, Liu P, Wang R, Zhang L, Zeng Q, Hu X, Bao Z, Wang S*. (2018) HD-Marker: a highly multiplexed and flexible approach for targeted genotyping of more than 10,000 genes in a single-tube assay. Genome Research. 28: 1919-1930.

10. Wang S#, Zhang J#, Jiao W#, Li J#, Xun X#, Sun Y#, Guo X#, Huan P#, Dong B, Zhang L, Hu X, Sun X, Wang J, Zhao C, Wang Y, Wang D, Huang X, Wang R, Lv J, Li Y, Zhang Z, Liu B, Lu W, Hui Y, Liang J, Zhou Z, Hou R, Li X, Liu Y, Li H, Ning X, Lin Y, Zhao L, Xing Q, Dou J, Li Y, Mao J, Guo H, Dou H, Li T, Mu C, Jiang W, Fu Q, Fu X, Miao Y, Liu J, Yu Q, Li R, Liao H, Li X, Kong Y, Jiang Z, Chourrout D*, Li R*, Bao Z*. (2017) Scallop genome provides insights into evolution of bilaterian karyotype and development. Nature Ecology & Evolution. 1: 0120.

11. Li Y#, Sun X#, Hu X#, Xun X#, Zhang J#, Guo X#, Jiao W, Zhang L, Liu W, Wang J, Li J, Sun Y, Miao Y, Zhang X, Cheng T, Xu G, Fu X, Wang Y, Yu X, Huang X, Lu W, Lv J, Mu C, Wang D, Li X, Xia Y, Li Y, Yang Z, Wang F, Zhang L, Xing Q, Dou H, Ning X, Dou J, Li Y, Kong D, Liu Y, Jiang Z, Li R, Wang S*, Bao Z*. (2017) Scallop genome reveals molecular adaptations to semi-sessile life and neurotoxins. Nature Communications. 8: 1721.

12. Dou J#, Dou H#, Mu C, Zhang L, Zhou Z, Chang Y, Wang J, Li T, Li Y, Hu X, Wang S*, Bao Z*. (2017) Whole-genome restriction mapping by “subhaploid”-based RAD sequencing: an efficient and flexible approach for physical mapping and genome scaffolding. Genetics. 206: 1237-1250.

13. Wang S#,*, Liu P#, Lv J, Li Y, Cheng T, Zhang L, Xia Y, Sun H, Hu X, Bao Z*. (2016) Serial sequencing of isolength RAD tags for cost-efficient genome-wide profiling of genetic and epigenetic variations. Nature Protocols. 11: 2189-2200.

14. Wang S#,*, Meyer E#,*, McKay JK, Matz MV. (2012) 2b-RAD: a simple and flexible method for genome-wide genotyping. Nature Methods. 9: 808-810.

15. Ponomarev I*,#, Wang S#, Zhang L, Harris RA & Mayfield RD*. (2012) Gene co-expression networks in human brain identify epigenetic modifications in alcohol dependence. Journal of Neuroscience. 32: 1884-1897.

16. Wang S*, Zhang L, Meyer E, Matz MV. (2009) Construction of a high-resolution genetic linkage map and comparative genome analysis for the reef-building coral Acropora millepora. Genome Biology.10: R126.

1.Wei J#, Liu P#, Liu F#, Jiang A, Qiao J, Pu Z, Wang B, Zhang J, Jia D, Li Y*, Wang S*, Dong B*. EDomics: a comprehensive and comparative multi-omics database for animal evo-devo. Nucleic Acids Research, 2022, gkac944. https://doi.org/10.1093/nar/gkac944.

2.Han W#, Liu L#, Wang J#, Wei H#, Li Y#, Zhang L#, Guo Z, Li Y, Liu T, Zeng Q, Xing Q, Shu Y, Wang T, Yang Y, Zhang M, Li R, Yu J, Pu Z, Lv J, Lian S, Hu J, Hu X, Bao Z, Bao L*, Zhang L*, Wang S*.  Ancient homomorphy of molluscan sex chromosomes sustained by reversible sex-biased genes and sex determiner translocation. Nature Ecology & Evolution., 2022.(In press)

3.Thimmappa R*, Wang S#, Zheng M#, Misra RC, Huang AC, Saalbach G, Chang Y, Zhou Z, Hinman V, Bao Z, Osbourn A*. Biosynthesis of saponin defensive compounds in sea cucumbers. Nature Chemical Biology, 2022, 18: 774-781. 

4.Sun Z#, Huang S#,*, Zhu P, Tzehau L, Zhao H, Lv J, Zhang R, Zhou L, Niu Q, Wang X, Zhang M, Jing G, Bao Z, Liu J, Wang S*, Xu J*. Species-resolved sequencing of low-biomass or degraded microbiomes using 2bRAD-M. Genome Biology, 2022, 23: 36.

5.Liu F, Li Y*, Yu H, Zhang L, Hu J, Bao Z, Wang S*. MolluscDB: an integrated functional and evolutionary genomics database for the hyper-diverse animal phylum Mollusca. Nucleic Acids Research, 2021,  49: D988-D997.

6.Bao Y#, Zeng Q#, Wang J#, Zhang Z#, Zhang Y#, Wang S#, Wong N#, Yuan W, Huang Y, Zhang W, Liu J, Lv L, Xue Q, Zha S, Peng Z, Yao H, Bao Z, Wang S*, Lin Z*. Genomic insights into the origin and evolution of molluscan red-bloodedness in the blood clam Tegillarca granosa. Molecular Biology and Evolution, 2021, 38: 2351-2365.

7.Wang J#, Zhang L#, Lian S#, Qin Z#, Zhu X#, Dai X, Huang Z, Ke C, Zhou Z, Wei J, Liu P, Hu N, Zeng Q, Dong B, Dong Y, Kong D, Zhang Z, Liu S, Xia Y, Li Y, Zhao L, Xing Q, Huang X, Hu X, Bao Z, Wang S*. Evolutionary transcriptomics of metazoan biphasic life cycle supports a single intercalation origin of metazoan larvae. Nature Ecology & Evolution , 2020, 4: 725-736.

8.Lv J#, Jiao W#, Guo H#, Liu P, Wang R, Zhang L, Zeng Q, Hu X, Bao Z, Wang S*. HD-Marker: a highly multiplexed and flexible approach for targeted genotyping of more than 10,000 genes in a single-tube assay. Genome Research, 2018, 28: 1919-1930.

9.Wang S#, Zhang J#, Jiao W#, Li J#, Xun X#, Sun Y#, Guo X#, Huan P#, Dong B, Zhang L, Hu X, Sun X, Wang J, Zhao C, Wang Y, Wang D, Huang X, Wang R, Lv J, Li Y, Zhang Z, Liu B, Lu W, Hui Y, Liang J, Zhou Z, Hou R, Li X, Liu Y, Li H, Ning X, Lin Y, Zhao L, Xing Q, Dou J, Li Y, Mao J, Guo H, Dou H, Li T, Mu C, Jiang W, Fu Q, Fu X, Miao Y, Liu J, Yu Q, Li R, Liao H, Li X, Kong Y, Jiang Z, Chourrout D*, Li R*, Bao Z*.  Scallop genome provides insights into evolution of bilaterian karyotype and development. Nature Ecology & Evolution, 2017, 1: 0120.

10.Li Y#, Sun X#, Hu X#, Xun X#, Zhang J#, Guo X#, Jiao W, Zhang L, Liu W, Wang J, Li J, Sun Y, Miao Y, Zhang X, Cheng T, Xu G, Fu X, Wang Y, Yu X, Huang X, Lu W, Lv J, Mu C, Wang D, Li X, Xia Y, Li Y, Yang Z, Wang F, Zhang L, Xing Q, Dou H, Ning X, Dou J, Li Y, Kong D, Liu Y, Jiang Z, Li R, Wang S*, Bao Z*.Scallop genome reveals molecular adaptations to semi-sessile life and neurotoxins. Nature Communications, 2017, 8: 1721.

11.Dou J#, Dou H#, Mu C, Zhang L, Zhou Z, Chang Y, Wang J, Li T, Li Y, Hu X, Wang S*, Bao Z*. Whole-genome restriction mapping by “subhaploid”-based RAD sequencing: an efficient and flexible approach for physical mapping and genome scaffolding. Genetics, 2017, 206: 1237-1250.

12.Wang S#,*, Liu P#, Lv J, Li Y, Cheng T, Zhang L, Xia Y, Sun H, Hu X, Bao Z*. Serial sequencing of isolength RAD tags for cost-efficient genome-wide profiling of genetic and epigenetic variations. Nature Protocols, 2016, 11: 2189-2200.

13.Wang S#,*, Meyer E#,*, McKay JK, Matz MV. 2b-RAD: a simple and flexible method for genome-wide genotyping. Nature Methods, 2012, 9: 808-810.

14.Ponomarev I*,#, Wang S#, Zhang L, Harris RA & Mayfield RD*. Gene co-expression networks in human brain identify epigenetic modifications in alcohol dependence. Journal of Neuroscience, 2012, 32: 1884-1897.

15.Wang S*, Zhang L, Meyer E, Matz MV.  Construction of a high-resolution genetic linkage map and comparative genome analysis for the reef-building coral Acropora millepora. Genome Biology, 2009, 10: R126.